Shetta biography template
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Robust SNP-based intimation of rheumy arthritis use up machine-learning-optimized polygenic risk score
- Research
- Open access
- Published:
- Ashley J. W. Lim1,
- C. Tera Tyniana2,
- Lee Jin Lim1,
- Justina Wei Lynn Tan3,
- Ee Tzun Koh3,
- TTSH Rheumy Arthritis Learn about Group,
- Samuel S. Chong4,
- Chiea Chuen Khor5,
- Khai Pang Leong3,9 &
- …
- Caroline G. LeeORCID: orcid.org/0000-0002-4323-36351,6,7,8
Journal remember Translational Medicinevolume 21, Article number: 92 (2023) Cite that article
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Abstract
Background
The popular statistics-based Genome-wide assemble studies (GWAS) have unsatisfactory deep insights into representation field constantly complex mess genetics. Regardless, its clinical applicability outline predict disease/trait outcomes remnants unclear significance statistical models are troupe designed in a jiffy make predictions. This lucubrate employs statistics-free machine-learning (ML)-optimized polygenic hazard score (PRS) to agree with existing GWAS and deliver the forecast of disease/trait outcomes finisher to clinical application. Arthritic Arthritis (RA) was designated as a model illness to establish the sturdiness of ML in ailment prediction despite the fact that RA deterioration a catholic chronic fiery joint infection with extreme mortality trimming
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Abstract
Liquid biopsy technologies have the potential to transform cancer patient management as it offers non-invasive diagnosis and real-time monitoring of disease progression and treatment responses. The use of liquid biopsy for non-invasive cancer diagnosis can have pivotal importance for the African continent where access to medical infrastructures is limited, as it eliminates the need for surgical biopsies. To apply liquid biopsy technologies in the African setting, the influence of environmental and population genetic factors must be known. In this review, we discuss the use of circulating tumor cells, cell-free nucleic acids, extracellular vesicles, protein, and other biomolecules in liquid biopsy technology for cancer management with special focus on African studies. We discussed the prospect, barriers, and other aspects that pose challenges to the use of liquid biopsy in the African continent.
Keywords: Africa, cancer, cell-free DNA, circulating tumor cell, circulating RNA, liquid biopsy, non-invasive
1. Introduction
Cancer is a growing public health threat globally. GLOBOCAN 2018 data showed an overall increase in cancer cases worldwide with 18.1 million new cases and 9.6 million cancer deaths in 2018 [1]. Africa and Asia were showed to have a higher proportio
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Srettha Thavisin
Prime Minister of Thailand from 2023 to 2024
Srettha ThavisinMPChMVM (Thai: เศรษฐา ทวีสิน, RTGS: Settha Thawisin, pronounced[sèːt.tʰǎːtʰā.wīː.sǐn]ⓘ; born 15 February 1962) is a Thai businessman and former politician who served as the 30th Prime Minister of Thailand from 2023[1] until his dismissal from the position by the Constitutional Court on 14 August 2024.[2][3] In 1988, he co-founded Sansiri, a venture that propelled him to become a billionaire and a leading real estate tycoon within his country.[4]
During his almost one-year premiership, he oversaw economic policies aimed at stimulating the Thai economy, particularly in Thailand's tourism sector by promoting Thai soft power. He also attempted to implement the digital wallet scheme and his international visits were aimed at attracting investors. Srettha was however labelled as a "puppet" under the control of powers behind the throne by critics.[5] His appointment of Pichit Chuenban to his cabinet led to his dismissal by the courts in August 2024.[6]
Early life and education
Srettha Thavisin, born on 15 February 1962,[7] in Bangkok, Thailand, is the only child of Captain Amnuay Thavisin and Chodchoy Thavi